Journal article
Ontogeny of Toll-Like and NOD-Like Receptor-Mediated innate immune responses in Papua New Guinean infants
PloS one, Vol.7(5)
2012
Abstract
Studies addressing the ontogeny of the innate immune system in early life have reported mainly on Toll-like receptor (TLR) responses in infants living in high-income countries, with little or even no information on other pattern recognition receptors or on early life innate immune responses in children living under very different environmental conditions in less-developed parts of the world. In this study, we describe whole blood innate immune responses to both Toll-like and nucleotide-binding oligomerization domain (NOD)-like receptor agonists including the widely used vaccine adjuvant ‘alum’ in a group of Papua New Guinean infants aged 1–3 (n = 18), 4–6 (n = 18), 7–12 (n = 21) and 13–18 (n = 10) months old. Depending on the ligands and cytokines studied, different age-related patterns were found: alum-induced IL-1β and CXCL8 responses were found to significantly decline with increasing age; inflammatory (IL-6, IL-1β, IFN-γ) responses to TLR2 and TLR3 agonists increased; and IL-10 responses remained constant or increased during infancy, while TNF-α responses either declined or remained the same. We report for the first time that whole blood innate immune responses to the vaccine adjuvant alum decrease with age in infancy; a finding that may imply that the adjuvant effect of alum in pediatric vaccines could be age-related. Our findings further suggest that patterns of innate immune development may vary between geographically diverse populations, which in line with the ‘hygiene hypothesis’ particularly involves persistence of innate IL-10 responses in populations experiencing higher infectious pressure.
Details
- Title
- Ontogeny of Toll-Like and NOD-Like Receptor-Mediated innate immune responses in Papua New Guinean infants
- Authors/Creators
- J.G. Lisciandro (Author/Creator)S.L. Prescott (Author/Creator)M.G. Nadal-Sims (Author/Creator)C.J. Devitt (Author/Creator)W. Pomat (Author/Creator)P.M. Siba (Author/Creator)M.C. Tulic (Author/Creator)P.G. Holt (Author/Creator)D. Strickland (Author/Creator)A.H.J. van den Biggelaar (Author/Creator)
- Publication Details
- PloS one, Vol.7(5)
- Publisher
- Public Library of Science
- Identifiers
- 991005544557707891
- Copyright
- © 2012 Lisciandro et al.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.609 Toll-like Receptors
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology