Phenotyping airway disease with optical coherence tomography

Harvey O. Coxson; Peter R. Eastwood; Jonathan P. Williamson; Don D. Sin

doi:10.1111/j.1440-1843.2010.01888.x

Back

Phenotyping airway disease with optical coherence tomography

Journal article

Peer reviewed

Phenotyping airway disease with optical coherence tomography

Harvey O. Coxson, Peter R. Eastwood, Jonathan P. Williamson and Don D. Sin

Respirology (Carlton, Vic.), Vol.16(1), pp.34-43

2011

DOI: https://doi.org/10.1111/j.1440-1843.2010.01888.x

PMID: 21044229

Files and links (1)

url

PublishedView

Published (Version of Record)

Abstract

airway disease

imaging

optical tomography

Airway diseases are a major concern around the world. However, the pace of new drug and biomarker discovery has lagged behind those of other common disorders such as cardiovascular diseases and diabetes. One major barrier in airway research has been the inability to accurately visualize large or small airway remodelling or dysplastic/neoplastic (either pre or early cancerous) changes using non- or minimally invasive instruments. The advent of optical coherence tomography (OCT) has the potential to revolutionize airway research and management by allowing investigators and clinicians to visualize the airway with resolution approaching histology and without exposing patients to harmful effects of ionizing radiation. Thus, with the aid of OCT, we may be able to accurately determine and quantify the extent of airway remodelling in asthma and chronic obstructive pulmonary disease, detect early pre-cancerous lesions in smokers for chemoprevention, study the upper airway anatomy of patients with obstructive sleep apnea in real time while they are asleep and facilitate optimal selection of stents for those with tracheal obstruction. In this paper, we review the current state of knowledge of OCT and its possible application in airway diseases.

Details

Title: Phenotyping airway disease with optical coherence tomography
Authors/Creators: Harvey O. Coxson - Providence College
Peter R. Eastwood - Sir Charles Gairdner Hospital
Jonathan P. Williamson - Sir Charles Gairdner Hospital
Don D. Sin - University of British Columbia
Publication Details: Respirology (Carlton, Vic.), Vol.16(1), pp.34-43
Publisher: Wiley
Number of pages: 10
Grant note: 513704 / NHMRC; National Health and Medical Research Council (NHMRC) of Australia 1P50 HL084948; R01 HL085096 / National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) P50HL084948; R01HL085096 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) 463926 / Australian NHMRC; National Health and Medical Research Council (NHMRC) of Australia
Identifiers: 991005592656207891
Murdoch Affiliation: Vice Chancellery
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

21 Record Views

16 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 5 Physics; 5.250 Imaging & Tomography; 5.250.1350 Optical Coherence Tomography
Web Of Science research areas: Respiratory System
ESI research areas: Clinical Medicine