Physical inactivity is associated with moderate-severe obstructive sleep apnea

Laila Simpson; Nigel McArdle; Peter R Eastwood; Kim L Ward; Matthew N Cooper; Annette C Wilson; David R Hillman; Lyle J Palmer; Sutapa Mukherjee

doi:10.5664/jcsm.5078

Journal article

Physical inactivity is associated with moderate-severe obstructive sleep apnea

Laila Simpson, Nigel McArdle, Peter R Eastwood, Kim L Ward, Matthew N Cooper, Annette C Wilson, David R Hillman, Lyle J Palmer and Sutapa Mukherjee

Journal of clinical sleep medicine, Vol.11(10), pp.1091-1099A

2015

DOI: https://doi.org/10.5664/jcsm.5078

PMCID: PMC4582050

PMID: 26285117

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Abstract

Study objectives: To investigate whether low levels of physical activity were associated with an increased occurrence of obstructive sleep apnea (OSA), OSA-related symptoms, and cardiometabolic risk. Methods: A case-control study design was used. OSA cases were patients referred to a sleep clinic for suspected OSA (n = 2,340). Controls comprised participants from the Busselton community (n = 1,931). Exercise and occupational activity were derived from questionnaire data. Associations were modelled using logistic and linear regression and adjusted for confounders. Results: In comparison with moderate exercise, the high, low, and nil exercise groups had an odds ratio (OR) for moderate-severe OSA of 0.6 (95% CI 0.5–0.8), 1.6 (95% CI 1.2–2.0), and 2.7 (95% CI 1.9–3.7), respectively. Relative to men in heavy activity occupations, men in medium, light and sedentary occupations had an OR for moderate-severe OSA of 1.7 (95% CI 1.1–2.5), 2.1 (95% CI 1.4–3.2), and 1.8 (95% CI 1.2–2.8), respectively. Relative to women in medium activity occupations, women in light and sedentary occupations had an OR for moderate-severe OSA of 4.2 (95% CI 2.6–7.2) and 3.5 (2.0–6.0). OSA patients who adequately exercised had lower: levels of doctor-diagnosed depression (p = 0.047); symptoms of fatigue (p < 0.0001); systolic (p = 0.015) and diastolic blood pressure (p = 0.015); and C-reactive protein (CRP) (p = 0.003). Conclusions: Low levels of physical activity were associated with moderate-severe OSA. Exercise in individuals with OSA is associated with lower levels of depression, fatigue, blood pressure and CRP.

Details

Title: Physical inactivity is associated with moderate-severe obstructive sleep apnea
Authors/Creators: Laila Simpson - The University of Western Australia
Nigel McArdle - The University of Western Australia
Peter R Eastwood - The University of Western Australia
Kim L Ward - The University of Western Australia
Matthew N Cooper - Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia
Annette C Wilson - West Australian Sleep Disorders Research Institute
David R Hillman - Sir Charles Gairdner Hospital
Lyle J Palmer - The University of Adelaide
Sutapa Mukherjee - West Australian Sleep Disorders Research Institute
Publication Details: Journal of clinical sleep medicine, Vol.11(10), pp.1091-1099A
Identifiers: 991005592763207891
Copyright: © 2015 American Academy of Sleep Medicine
Murdoch Affiliation: Vice Chancellery
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.137 Sleep Science & Circadian Systems; 1.137.382 Obstructive Sleep Apnea
Web Of Science research areas: Clinical Neurology
ESI research areas: Neuroscience & Behavior