Plasma cytokine profiles in very preterm infants with late-onset sepsis

J. Hibbert; T. Strunk; K. Simmer; P. Richmond; D. Burgner; A. Currie

doi:10.1371/journal.pone.0232933

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Plasma cytokine profiles in very preterm infants with late-onset sepsis

Journal article

Open access

Peer reviewed

Plasma cytokine profiles in very preterm infants with late-onset sepsis

J. Hibbert, T. Strunk, K. Simmer, P. Richmond, D. Burgner and A. Currie

PLoS ONE, Vol.15(5), e0232933

2020

DOI: https://doi.org/10.1371/journal.pone.0232933

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Abstract

Introduction Deficiencies in innate immune responses may contribute to the increased susceptibility to infection in preterm infants. In vivo cytokine profiles in response to sepsis in very preterm infants are not fully understood. Aims To characterise plasma pro- and anti-inflammatory cytokine concentrations and pre-defined ratios in very preterm infants with late-onset sepsis (LOS). Methods In this observational study, peripheral blood samples were collected at the time of evaluation for suspected LOS from 31 preterm infants (<30 weeks gestational age). Plasma cytokine concentrations were determined by 12-plex immunoassay. Results IL-10, IFN-γ, IL-12p70, IP-10, IL-6 and CCL2 were elevated in the majority infants with LOS (n = 12) compared to those without LOS (n = 19). There was no difference in TNF-α, IL-1β, IL-17AF, IL-8 and IL-15 concentrations between groups. IL-10/TNF-α ratios were increased, while CCL2/IL-10 and IL-12p70/IL-10 ratios were decreased in infants with LOS compared to those without. Conclusion Very preterm infants have a marked innate inflammatory response at the time of LOS. The increase in IL-10/TNF-α ratio may indicate early immune hypo-responsiveness. Longitudinal studies with a larger number of participants are required to understand immune responses and clinical outcomes following LOS in preterm infants.

Details

Title: Plasma cytokine profiles in very preterm infants with late-onset sepsis
Authors/Creators: J. Hibbert (Author/Creator) - The University of Western Australia
T. Strunk (Author/Creator) - The University of Western Australia
K. Simmer (Author/Creator) - The University of Western Australia
P. Richmond (Author/Creator) - The University of Western Australia
D. Burgner (Author/Creator) - The University of Melbourne
A. Currie (Author/Creator) - The University of Western Australia
Publication Details: PLoS ONE, Vol.15(5), e0232933
Publisher: Public Library of Science
Identifiers: 991005541265107891
Copyright: © 2020 Hibbert et al.
Murdoch Affiliation: School of Medical, Molecular and Forensic Sciences; Centre for Molecular Medicine and Innovative Therapeutics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.23 Antibiotics & Antimicrobials; 1.23.1757 Group B Streptococcus
Web Of Science research areas: Immunology
ESI research areas: Clinical Medicine