Journal article
Preterm infants have deficient monocyte and lymphocyte cytokine responses to Group B Streptococcus
Infection and Immunity, Vol.79(4), pp.1588-1596
2011
Abstract
Group B streptococcus GBS) is an important cause of early-and late-onset sepsis in the newborn. Preterm infants have markedly increased susceptibility and worse outcomes, but their immunological responses to GBS are poorly defined. We compared mononuclear cell and whole-blood cytokine responses to heat-killed GBS HKGBS) of preterm infants gestational age [GA], 26 to 33 weeks), term infants, and healthy adults. We investigated the kinetics and cell source of induced cytokines and quantified HKGBS phagocytosis. HKGBS-induced tumor necrosis factor TNF) and interleukin 6 (IL-6) secretion was significantly impaired in preterm infants compared to that in term infants and adults. These cytokines were predominantly monocytic in origin, and production was intrinsically linked to HKGBS phagocytosis. Very preterm infants GA, < 30 weeks) had fewer cytokine-producing monocytes, but nonopsonic phagocytosis ability was comparable to that for term infants and adults. Exogenous complement supplementation increased phagocytosis in all groups, as well as the proportion of preterm monocytes producing IL-6, but for very preterm infants, responses were still deficient. Similar defective preterm monocyte responses were observed in fresh whole cord blood stimulated with live GBS. Lymphocyte-associated cytokines were significantly deficient for both preterm and term infants compared to levels for adults. These findings indicate that a subset of preterm monocytes do not respond to GBS, a defect compounded by generalized weaker lymphocyte responses in newborns. Together these deficient responses may increase the susceptibility of preterm infants to GBS infection.
Details
- Title
- Preterm infants have deficient monocyte and lymphocyte cytokine responses to Group B Streptococcus
- Authors/Creators
- A.J. Currie (Author/Creator) - The University of Western AustraliaS. Curtis (Author/Creator) - The University of Western AustraliaT. Strunk (Author/Creator) - The University of Western AustraliaK. Riley (Author/Creator) - The University of Western AustraliaK. Liyanage (Author/Creator) - The University of Western AustraliaS. Prescott (Author/Creator) - The University of Western AustraliaD. Doherty (Author/Creator) - The University of Western AustraliaK. Simmer (Author/Creator) - The University of Western AustraliaP. Richmond (Author/Creator) - The University of Western AustraliaD. Burgner (Author/Creator) - Royal Children's Hospital
- Publication Details
- Infection and Immunity, Vol.79(4), pp.1588-1596
- Publisher
- American Society for Microbiology
- Identifiers
- 991005544991507891
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.1757 Group B Streptococcus
- Web Of Science research areas
- Immunology
- Infectious Diseases
- ESI research areas
- Immunology