Probiotics and antimicrobial protein and peptide levels in preterm infants

T. Strunk; J. Hibbert; D. Doherty; C. Granland; S. Trend; K. Simmer; D. Burgner; S. Patole; A. Currie

doi:10.1111/apa.13826

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Probiotics and antimicrobial protein and peptide levels in preterm infants

Journal article

Open access

Peer reviewed

Probiotics and antimicrobial protein and peptide levels in preterm infants

T. Strunk, J. Hibbert, D. Doherty, C. Granland, S. Trend, K. Simmer, D. Burgner, S. Patole and A. Currie

Acta Paediatrica, Vol.106(11), pp.1747-1753

2017

DOI: https://doi.org/10.1111/apa.13826

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Abstract

Aim To characterise the secreted and inducible antimicrobial protein and peptide (APP) levels in a prospective cohort of preterm infants (<30 weeks gestational age) with or without Bifidobacterium breve M16V supplementation during the first month of life. Methods We analysed serial biosamples of infants who did (n = 13) or did not receive (n = 62) B. breve (3 × 109 cfu/day). Peripheral blood was obtained on days 1, 14 and 28, and infant stool prior to commencement of probiotic supplementation and on day 21. Levels of APP (bactericidal/permeability inducing protein (BPI), beta defensins 1 and 2, lactoferrin, human cathelicidin, secretory phospholipase A2) in plasma and stool were determined. Further, we characterised induced APP levels in whole blood cultured with live S. epidermidis or with agonists of Toll-like receptors 2/6 and 4. Results Stool, plasma and stimulated blood APP levels changed significantly during the first month of life. Supplementation with B. breve did not affect basal or stimulated APP levels except for a transient increase in inducible BPI. Conclusion Supplementation with B. breve does not appear to act via modulation of systemic or enteric APP expression in preterm infants although small effects cannot be excluded. Further work with other probiotic preparations is warranted.

Details

Title: Probiotics and antimicrobial protein and peptide levels in preterm infants
Authors/Creators: T. Strunk (Author/Creator) - The University of Western Australia
J. Hibbert (Author/Creator) - The University of Western Australia
D. Doherty (Author/Creator) - The University of Western Australia
C. Granland (Author/Creator) - The University of Western Australia
S. Trend (Author/Creator) - The University of Western Australia
K. Simmer (Author/Creator) - The University of Western Australia
D. Burgner (Author/Creator) - The University of Melbourne
S. Patole (Author/Creator) - The University of Western Australia
A. Currie (Author/Creator) - The University of Western Australia
Publication Details: Acta Paediatrica, Vol.106(11), pp.1747-1753
Publisher: John Wiley & Sons Ltd
Identifiers: 991005544726907891
Copyright: ©2017 Foundation Acta Pædiatrica
Murdoch Affiliation: School of Veterinary and Life Sciences; Centre for Molecular Medicine and Innovative Therapeutics; School of Medical, Molecular and Forensic Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.120 Inflammatory Bowel Diseases & Infections; 1.120.384 Gut Microbiota
Web Of Science research areas: Pediatrics
ESI research areas: Clinical Medicine