Journal article
Quantitative upper airway imaging with anatomic optical coherence tomography
American journal of respiratory and critical care medicine, Vol.173(2), pp.226-233
2006
PMID: 16239620
Abstract
Background:
Measurements of upper airway size and shape are important in investigating the pathophysiology of obstructive sleep apnea (OSA) and in devising, applying, and determining the effectiveness of treatment modalities. We describe an endoscopic optical technique (anatomic optical coherence tomography, aOCT) that provides quantitative real-time imaging of the internal anatomy of the human upper airway.
Methods:
Validation studies were performed by comparing aOCT- and computed tomography (CT)–derived measurements of cross-sectional area (CSA) in (1) conduits in a wax phantom and (2) the velo-, oro-, and hypopharynx during wakefulness in five volunteers. aOCT scanning was performed during sleep in one subject with OSA.
Results:
aOCT generated images of pharyngeal shape and measurements of CSA and internal dimensions that were comparable to radiographic CT images. The mean difference between aOCT- and CT-derived measurements of CSA in (1) the wax phantom was 2.1 mm2 with limits of agreement (2 SD) from −13.2 to 17.4 mm2 and intraclass correlation coefficient of 0.99 (p < 0.001) and (2) the pharyngeal airway was 14.1 mm2 with limits of agreement from −43.7 to 57.8 mm2 and intraclass correlation coefficient of 0.89 (p < 0.001). aOCT generated quantitative images of changes in upper airway size and shape before, during, and after an apneic event in an individual with OSA.
Conclusions:
aOCT generates quantitative, real-time measurements of upper airway size and shape with minimal invasiveness, allowing study over lengthy periods during both sleep and wakefulness. These features should make it useful for study of upper airway behavior to investigate OSA pathophysiology and aid clinical management.
Details
- Title
- Quantitative upper airway imaging with anatomic optical coherence tomography
- Authors/Creators
- Julian J Armstrong - The University of Western AustraliaMatthew S Leigh - West Australian Sleep Disorders Research InstituteDavid D Sampson - The University of Western AustraliaJennifer H Walsh - Sir Charles Gairdner HospitalDavid R Hillman - The University of Western AustraliaPeter R Eastwood - West Australian Sleep Disorders Research Institute
- Publication Details
- American journal of respiratory and critical care medicine, Vol.173(2), pp.226-233
- Publisher
- American Lung Association
- Identifiers
- 991005591571107891
- Copyright
- © 2006 The American Thoracic Society
- Murdoch Affiliation
- Vice Chancellery
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 5 Physics
- 5.250 Imaging & Tomography
- 5.250.1350 Optical Coherence Tomography
- Web Of Science research areas
- Critical Care Medicine
- Respiratory System
- ESI research areas
- Clinical Medicine