Relationships between ventilatory impairment, sleep hypoventilation and type 2 respiratory failure

David Hillman; Bhajan Singh; Nigel Mcardle; Peter Eastwood

doi:10.1111/resp.12376

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Relationships between ventilatory impairment, sleep hypoventilation and type 2 respiratory failure

Journal article

Peer reviewed

Relationships between ventilatory impairment, sleep hypoventilation and type 2 respiratory failure

David Hillman, Bhajan Singh, Nigel Mcardle and Peter Eastwood

Respirology (Carlton, Vic.), Vol.19(8), pp.1106-1116

2014

DOI: https://doi.org/10.1111/resp.12376

PMID: 25219542

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Abstract

chronic obstructive pulmonary disease

hypercapnic respiratory failure

neuromuscular disorder

obesity

sleep hypoventilation

Conditions that increase load on respiratory muscles and/or reduce their capacity to cope with this load predispose to type 2 (hypercapnic) respiratory failure. In its milder forms, this imbalance between load and capacity may primarily manifest as sleep hypoventilation which, if untreated, can increase the likelihood of wakeful respiratory failure. Such problems are commonly seen in progressive respiratory neuromuscular disorders, morbid obesity and chronic obstructive pulmonary disease, either separately or together. Identifying patients at risk can be important in determining whether and when to intervene with treatments such as non-invasive ventilatory assistance. Measurements of wakeful respiratory function are fundamental to this risk assessment. These issues are reviewed in this paper.

Details

Title: Relationships between ventilatory impairment, sleep hypoventilation and type 2 respiratory failure
Authors/Creators: David Hillman - Sir Charles Gairdner Hospital
Bhajan Singh - Sir Charles Gairdner Hospital
Nigel Mcardle - Sir Charles Gairdner Hospital
Peter Eastwood - Sir Charles Gairdner Hospital
Publication Details: Respirology (Carlton, Vic.), Vol.19(8), pp.1106-1116
Publisher: Wiley
Number of pages: 11
Grant note: 1042341 / Australian National Health and Medical Research Council; National Health and Medical Research Council (NHMRC) of Australia
Identifiers: 991005591575907891
Murdoch Affiliation: Vice Chancellery
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.137 Sleep Science & Circadian Systems; 1.137.382 Obstructive Sleep Apnea
Web Of Science research areas: Respiratory System
ESI research areas: Clinical Medicine