Files and links (2)
Published (Version of Record)CC BY-NC V4.0, Open Access
Journal article
Repetitive low intensity magnetic field stimulation in a neuronal cell line: a metabolomics study
PeerJ, Vol.6, e4501
2018
Abstract
Low intensity repetitive magnetic stimulation of neural tissue modulates neuronal excitability and has promising therapeutic potential in the treatment of neurological disorders. However, the underpinning cellular and biochemical mechanisms remain poorly understood. This study investigates the behavioural effects of low intensity repetitive magnetic stimulation (LI-rMS) at a cellular and biochemical level. We delivered LI-rMS (10 mT) at 1 Hz and 10 Hz to B50 rat neuroblastoma cells in vitro for 10 minutes and measured levels of selected metabolites immediately after stimulation. LI-rMS at both frequencies depleted selected tricarboxylic acid (TCA) cycle metabolites without affecting the main energy supplies. Furthermore, LI-rMS effects were frequency-specific with 1 Hz stimulation having stronger effects than 10 Hz. The observed depletion of metabolites suggested that higher spontaneous activity may have led to an increase in GABA release. Although the absence of organised neural circuits and other cellular contributors (e.g., excitatory neurons and glia) in the B50 cell line limits the degree to which our results can be extrapolated to the human brain, the changes we describe provide novel insights into how LI-rMS modulates neural tissue.
Details
- Title
- Repetitive low intensity magnetic field stimulation in a neuronal cell line: a metabolomics study
- Authors/Creators
- I. Hong (Author/Creator)A. Garrett (Author/Creator) - The University of Western AustraliaG. Maker (Author/Creator) - Murdoch UniversityI. Mullaney (Author/Creator) - Murdoch UniversityJ. Rodger (Author/Creator) - The University of Western AustraliaS.J. Etherington (Author/Creator) - Murdoch University
- Publication Details
- PeerJ, Vol.6, e4501
- Publisher
- PeerJ Inc.
- Identifiers
- 991005540952007891
- Copyright
- © 2018 Hong et al
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
91 File views/ downloads
94 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.82 Gait & Posture
- 1.82.811 Transcranial Magnetic Stimulation
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior