Journal article
Resting-state fMRI study of brain activation using low-intensity repetitive transcranial magnetic stimulation in rats
Scientific Reports, Vol.8, Article number: 6706
2018
Abstract
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique used to treat many neuropsychiatric conditions. However, the mechanisms underlying its mode of action are still unclear. This is the first rodent study using resting-state functional MRI (rs-fMRI) to examine low-intensity (LI) rTMS effects, in an effort to provide a direct means of comparison between rodent and human studies. Using anaesthetised Sprague-Dawley rats, rs-fMRI data were acquired before and after control or LI-rTMS at 1 Hz, 10 Hz, continuous theta burst stimulation (cTBS) or biomimetic high-frequency stimulation (BHFS). Independent component analysis revealed LI-rTMS-induced changes in the resting-state networks (RSN): (i) in the somatosensory cortex, the synchrony of resting activity decreased ipsilaterally following 10 Hz and bilaterally following 1 Hz stimulation and BHFS, and increased ipsilaterally following cTBS; (ii) the motor cortex showed bilateral changes following 1 Hz and 10 Hz stimulation, a contralateral decrease in synchrony following BHFS, and an ipsilateral increase following cTBS; and (iii) hippocampal synchrony decreased ipsilaterally following 10 Hz, and bilaterally following 1 Hz stimulation and BHFS. The present findings demonstrate that LI-rTMS modulates functional links within the rat RSN with frequency-specific outcomes, and the observed changes are similar to those described in humans following rTMS.
Details
- Title
- Resting-state fMRI study of brain activation using low-intensity repetitive transcranial magnetic stimulation in rats
- Authors/Creators
- B.J. Seewoo (Author/Creator) - The University of Western AustraliaK.W. Feindel (Author/Creator) - The University of Western AustraliaS.J. Etherington (Author/Creator) - Murdoch UniversityJ. Rodger (Author/Creator) - The University of Western Australia
- Publication Details
- Scientific Reports, Vol.8, Article number: 6706
- Publisher
- Nature Publishing Group, a division of Macmillan Publishers Limited
- Identifiers
- 991005542038807891
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.82 Gait & Posture
- 1.82.811 Transcranial Magnetic Stimulation
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior