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Published (Version of Record)CC BY-NC V4.0, Open Access
Journal article
Restoration of defective cross-presentation in tumors by gemcitabine
OncoImmunology, Vol.4(5)
2015
Abstract
Tumor antigen cross-presentation by dendritic cells (DCs) to specific CD8(+) T cells is central to antitumor immunity. Although highly efficient in draining lymph nodes, it is defective within the tumor site itself. Importantly, an immunogenic chemotherapy, gemcitabine, reverses this defect, allowing the potential re-stimulation of cytotoxic T lymphocytes within tumor sites.
Details
- Title
- Restoration of defective cross-presentation in tumors by gemcitabine
- Authors/Creators
- A.M McDonnell (Author/Creator) - The University of Western AustraliaW. Joost Lesterhuis (Author/Creator)A. Khong (Author/Creator) - The University of Western AustraliaA.K Nowak (Author/Creator) - The University of Western AustraliaR.A. Lake (Author/Creator) - The University of Western AustraliaA.J. Currie (Author/Creator) - Murdoch UniversityB.W.S. Robinson (Author/Creator) - The University of Western Australia
- Publication Details
- OncoImmunology, Vol.4(5)
- Publisher
- Taylor & Francis
- Identifiers
- 991005541136107891
- Copyright
- © The Authors
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.358 Dendritic Cell Therapy
- Web Of Science research areas
- Immunology
- Oncology
- ESI research areas
- Biology & Biochemistry