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Published (Version of Record)CC BY V4.0, Open Access
Journal article
Sepsis-Induced Immunosuppression in Neonates
Frontiers in Pediatrics, Vol.6, 00357
2018
Abstract
Neonates, especially those born preterm, are at increased risk of sepsis and adverse long-term effects associated with infection-related inflammation. Distinct neonatal immune responses and dysregulated inflammation are central to this unique susceptibility. The traditional separation of sepsis into an initial hyper-inflammatory response followed by hypo-inflammation is continually under review with new developments in this area of research. There is evidence to support the association of mortality in the early acute phase of sepsis with an overwhelming hyper-inflammatory immune response. Emerging evidence from adults suggests that hypo- and hyper-inflammation can occur during any phase of sepsis and that sepsis-immunosuppression is associated with increased mortality, morbidity, and risk to subsequent infection. In adults, sepsis-induced immunosuppression (SII) is characterised by alterations of innate and adaptive immune responses, including, but not limited to, a prominent bias toward anti-inflammatory cytokine secretion, diminished antigen presentation to T cells, and reduced activation and proliferation of T cells. It is unclear if sepsis-immunosuppression also plays a role in the adverse outcomes associated with neonatal sepsis. This review will focus on exploring if key characteristics associated with SII in adults are observed in neonates with sepsis.
Details
- Title
- Sepsis-Induced Immunosuppression in Neonates
- Authors/Creators
- J.E. Hibbert (Author/Creator)A. Currie (Author/Creator)T. Strunk (Author/Creator)
- Publication Details
- Frontiers in Pediatrics, Vol.6, 00357
- Publisher
- Frontiers Media S.A.
- Identifiers
- 991005542964507891
- Copyright
- © 2018 Hibbert, Currie and Strunk.
- Murdoch Affiliation
- School of Veterinary and Life Sciences; Centre for Molecular Medicine and Innovative Therapeutics; School of Medical, Molecular and Forensic Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.1757 Group B Streptococcus
- Web Of Science research areas
- Pediatrics
- ESI research areas
- Clinical Medicine