Skin-Microbiome Assembly in Preterm Infants during the First Three Weeks of Life and Impact of Topical Coconut Oil Application

Noor-Ul-Huda Ghori; Christopher A. Mullally; Mark P. Nicol; Andrew Currie; Julie Hibbert; Matthew S. Payne; Sanjay Patole; Tobias Strunk

doi:10.3390/ijms242316626

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Skin-Microbiome Assembly in Preterm Infants during the First Three Weeks of Life and Impact of Topical Coconut Oil Application

Journal article

Open access

Peer reviewed

Skin-Microbiome Assembly in Preterm Infants during the First Three Weeks of Life and Impact of Topical Coconut Oil Application

Noor-Ul-Huda Ghori, Christopher A. Mullally, Mark P. Nicol, Andrew Currie, Julie Hibbert, Matthew S. Payne, Sanjay Patole and Tobias Strunk

International journal of molecular sciences, Vol.24(23), 16626

2023

DOI: https://doi.org/10.3390/ijms242316626

PMID: 38068949

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Abstract

Biochemistry & Molecular Biology

Chemistry

Chemistry, Multidisciplinary

Life Sciences & Biomedicine

Physical Sciences

Science & Technology

The structure and function of infant skin is not fully developed until 34 weeks of gestation, and this immaturity is associated with risk of late-onset sepsis (LOS). Topical coconut oil improves preterm-infant skin integrity and may reduce LOS. However, data on early-life skin-microbiome succession and potential effects of emollient skin care in preterm infants are scarce. We therefore collected skin-microbiome samples from the ear, axilla, and groin on days 1, 7, 14, and 21 from preterm infants born <30 weeks of gestation as part of a randomized clinical trial of standard skin care vs. topical coconut oil. We found that within-sample microbiome diversity was highest on day 1 after birth, with a subsequent decline and emergence of Staphylococcus genus dominance from day 7. Moreover, microbiome assembly was less diverse in infants receiving coconut oil vs. standard skin care. Our study provides novel data on preterm-infant skin-microbiome composition and highlights the modifying potential of emollient skin care.

Details

Title: Skin-Microbiome Assembly in Preterm Infants during the First Three Weeks of Life and Impact of Topical Coconut Oil Application
Authors/Creators: Noor-Ul-Huda Ghori - The University of Western Australia
Christopher A. Mullally - Telethon Kids Inst, Wesfarmers Ctr Vaccines & Infect Dis, Perth 6009, Australia
Mark P. Nicol - The University of Western Australia
Andrew Currie - Murdoch University, Centre for Molecular Medicine and Innovative Therapeutics
Julie Hibbert - The Kids Research Institute Australia
Matthew S. Payne - The University of Western Australia
Sanjay Patole - King Edward Memorial Hospital
Tobias Strunk - Telethon Kids Inst, Wesfarmers Ctr Vaccines & Infect Dis, Perth 6009, Australia
Publication Details: International journal of molecular sciences, Vol.24(23), 16626
Publisher: MDPI
Number of pages: 16
Grant note: Channel 7 Telethon Trust and the Women and Infants Research Foundation
Identifiers: 991005623666907891
Murdoch Affiliation: Centre for Molecular Medicine and Innovative Therapeutics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.120 Inflammatory Bowel Diseases & Infections; 1.120.384 Gut Microbiota
Web Of Science research areas: Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
ESI research areas: Chemistry