Journal article
Temporal relationship between night-time gastroesophageal reflux events and arousals from sleep
The American journal of gastroenterology, Vol.115(5), pp.697-705
2020
PMID: 32356952
Abstract
INTRODUCTION:
Night-time gastroesophageal reflux (nGER) symptoms are commonly associated with interrupted sleep. Most studies attempting to understand the relationship between sleep, arousal, and nGER events have been performed so using accelerometry; however, this technology is limited in its ability to precisely determine the temporal association between sleep and reflux events. We aimed to examine the temporal relationships between nGER events and arousal/awakening from sleep using high resolution, in-laboratory polysomnography (PSG).
METHODS:
Individuals between 18 and 70 years who had undergone a gastroscopy within 12 months underwent simultaneous 24-hour pH/impedance monitoring and in-laboratory PSG. The temporal relationship between each nGER event and sleep/arousals/awakenings was determined for each participant. Analyses were limited to the sleep period (between “lights out” and time of final waking).
RESULTS:
Analyses were conducted on the data from 25 individuals, 64% of whom had nGER episodes (5 ± 5 events per person, range 1–18) and 64% of whom had obstructive sleep apnea (OSA, mean apnea–hypopnea index 20 ± 11 events/hr, range 6–44). There were no differences in PSG-determined sleep duration, sleep efficiency, sleep architecture, arousals/awakenings, or sleep apnea severity between those with nGER and those without. Most nGER events (82%) occurred during a PSG epoch that had been classified as wake. Arousals/awakenings preceded almost all events (73/76), whereas fewer had an arousal/awakening after the event (15/76).
DISCUSSION:
As opposed to what is typically assumed, nGER does not seem to cause arousal from sleep, but rather arousal from sleep predisposes to nGER.
Details
- Title
- Temporal relationship between night-time gastroesophageal reflux events and arousals from sleep
- Authors/Creators
- Kelly Shepherd - West Australian Sleep Disorders Research InstituteJames Ockelford - West Australian Sleep Disorders Research InstituteVijeyadezmi Ganasan - West Australian Sleep Disorders Research InstituteRichard Holloway - Royal Adelaide HospitalDavid Hillman - West Australian Sleep Disorders Research InstitutePeter Eastwood - West Australian Sleep Disorders Research Institute
- Publication Details
- The American journal of gastroenterology, Vol.115(5), pp.697-705
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 9
- Grant note
- 1136548 / NHMRC; National Health and Medical Research Council (NHMRC) of Australia 10316178 / NationalHealth and Medical Research Council; National Health and Medical Research Council (NHMRC) of Australia
- Identifiers
- 991005591571507891
- Copyright
- © 2020 by The American College of Gastroenterology
- Murdoch Affiliation
- Vice Chancellery
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.95 Gastrointestinal & Esophageal Diseases
- 1.95.541 GERD & Achalasia
- Web Of Science research areas
- Gastroenterology & Hepatology
- ESI research areas
- Clinical Medicine