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Journal article
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
European journal of epidemiology, Vol.34(3), pp.279-300
2019
PMCID: PMC6447695
PMID: 30887376
Abstract
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
Details
- Title
- The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
- Authors/Creators
- Christel M Middeldorp - The University of QueenslandJanine F Felix - Erasmus MCAnubha Mahajan - Centre for Human GeneticsMark I McCarthy - Churchill HospitalEArly Genetics Lifecourse Epidemiology (EAGLE) consortiumPeter Eastwood
- Publication Details
- European journal of epidemiology, Vol.34(3), pp.279-300
- Grant note
- MC_UU_12013/5 / Medical Research Council 104150 / Wellcome Trust MC_U147585824 / Medical Research Council U01 LM012675 / NLM NIH HHS MC_U147585819 / Medical Research Council MC_U147585827 / Medical Research Council G0400491 / Medical Research Council MC_UU_12011/1 / Medical Research Council MC_UU_00011/1 / Medical Research Council G0601361 / Medical Research Council MR/L01341X/1 / Medical Research Council G9815508 / Medical Research Council MC_PC_15018 / Medical Research Council P50 HD028138 / NICHD NIH HHS MC_UU_12013/4 / Medical Research Council MC_UP_A620_1014 / Medical Research Council MR/K002449/1 / Medical Research Council P30 ES007048 / NIEHS NIH HHS
- Identifiers
- 991005592762907891
- Copyright
- © The Author(s) 2019
- Murdoch Affiliation
- Vice Chancellery
- Language
- English
- Resource Type
- Journal article
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