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CC BY V4.0, Open Access
Journal article
The interrelationships between sleep regularity, obstructive sleep apnea and hypertension in a middle-aged community population
Sleep (New York, N.Y.), Vol.47, pp.1-12
2024
PMID: 38180870
Abstract
Study Objectives
Little is known about the inter-relationships between sleep regularity, obstructive sleep apnea (OSA) and important health markers. This study examined whether irregular sleep is associated with OSA and hypertension, and if this modifies the known association between OSA and hypertension.
Methods
602 adults (age mean(SD) =56.96(5.51) years, female=60%) from the Raine Study who were not evening or night shift workers were assessed for OSA (in-laboratory polysomnography; apnea hypopnea index (AHI) ≥15events/hour), hypertension (doctor diagnosed; or systolic blood pressure ≥140mmHg and/or diastolic ≥90mmHg) and sleep (wrist actigraphy for ≥5 days). A sleep regularity index (SRI) was determined from actigraphy. Participants were categorised by tertiles as severely irregular, mildly irregular, or regular sleepers. Logistic regression models examined the interrelationships between SRI, OSA and hypertension. Covariates included age, sex, body mass index, actigraphy sleep duration, insomnia, depression, activity, alcohol, smoking, and anti-hypertensive medication.
Results
Compared to regular sleepers, participants with mildly irregular (OR 1.97, 95% CI 1.20-3.27) and severely irregular (OR 2.06, 95% CI 1.25–3.42) sleep had greater odds of OSA. Compared to those with no OSA and regular sleep, OSA and severely irregular sleep combined had the highest odds of hypertension (OR 2.34 95% CI 1.07-5.12; p for interaction=0.02) while those with OSA and regular/mildly irregular sleep were not at increased risk (p for interaction=0.20).
Conclusions
Sleep irregularity may be an important modifiable target for hypertension among those with OSA.
Details
- Title
- The interrelationships between sleep regularity, obstructive sleep apnea and hypertension in a middle-aged community population
- Authors/Creators
- Kelly Sansom - Flinders UniversityAmy Reynolds - Flinders UniversityDaniel Windred - Monash UniversityAndrew Phillips - Monash UniversitySatvinder S Dhaliwal - Universiti Sains MalaysiaJennifer Walsh - Sir Charles Gairdner HospitalKathleen Maddison - Sir Charles Gairdner HospitalBhajan Singh - Sir Charles Gairdner HospitalPeter Eastwood - Health Futures Institute, Murdoch University, Perth, WA, AustraliaNigel McArdle - Sir Charles Gairdner Hospital
- Publication Details
- Sleep (New York, N.Y.), Vol.47, pp.1-12
- Publisher
- Oxford University Press on behalf of Sleep Research Society.
- Identifiers
- 991005625269307891
- Copyright
- © The Author(s) 2024.
- Murdoch Affiliation
- Vice Chancellery
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.137 Sleep Science & Circadian Systems
- 1.137.349 Insomnia
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior