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Total Synthesis and Structural Reassignment of the Molt-Inhibiting Marine Alkaloid Erebusinone
Journal article   Peer reviewed

Total Synthesis and Structural Reassignment of the Molt-Inhibiting Marine Alkaloid Erebusinone

Louisa Tham, Brodie W Bulcock, Samuele Sala, Gareth L Nealon, Gavin R Flematti, Stephen A Moggach and Matthew J Piggott
Journal of natural products (Washington, D.C.), Online ahead of print
2024
PMID: 39365948

Abstract

The marine alkaloid erebusinone is a secondary metabolite isolated from the Antarctic sponge Isodictya erinacea. Initial biological assays have shown that erebusinone increases amphipod mortality, probably by inhibition of the biosynthesis of molting hormone (ecdysone). Herein, we report the first total synthesis of the proposed structure of erebusinone and a structural revision.

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Citation topics
3 Agriculture, Environment & Ecology
3.198 Mycotoxins
3.198.749 Porifera
Web Of Science research areas
Chemistry, Medicinal
Pharmacology & Pharmacy
Plant Sciences
ESI research areas
Pharmacology & Toxicology
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