Tumor cells, rather than dendritic cells, deliver antigen to the lymph node for cross-presentation

A.M. McDonnell; A.J. Currie; M. Brown; K. Kania; B. Wylie; A. Cleaver; R. Lake; B.W.S. Robinson

doi:10.4161/onci.20493

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Tumor cells, rather than dendritic cells, deliver antigen to the lymph node for cross-presentation

Journal article

Open access

Peer reviewed

Tumor cells, rather than dendritic cells, deliver antigen to the lymph node for cross-presentation

A.M. McDonnell, A.J. Currie, M. Brown, K. Kania, B. Wylie, A. Cleaver, R. Lake and B.W.S. Robinson

OncoImmunology, Vol.1(6), pp.840-846

2012

DOI: https://doi.org/10.4161/onci.20493

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Abstract

It is widely accepted that generation of tumor specific CD8+ T-cell responses occur via cross-priming; however the source of tumor antigen for this event is unknown. We examined the source and form of tumor antigen required for cross-presentation in the local lymph node (LN) using a syngeneic mouse tumor model expressing a marker antigen. We found that cross-presentation of this model tumor antigen in the LN is dependent on continuous traffic of antigen from the tumor site, but without any detectable migration of tumor resident dendritic cells (DCs). Instead, small numbers of tumor cells metastasize to local LNs where they are exposed to a localized CTL attack, resulting in delivery of tumor antigen into the cross-presentation pathway.

Details

Title: Tumor cells, rather than dendritic cells, deliver antigen to the lymph node for cross-presentation
Authors/Creators: A.M. McDonnell (Author/Creator) - The University of Western Australia
A.J. Currie (Author/Creator) - School of Paediatrics and Child Health
M. Brown (Author/Creator) - The University of Western Australia
K. Kania (Author/Creator) - National Centre for Asbestos Related Diseases
B. Wylie (Author/Creator) - School of Paediatrics and Child Health
A. Cleaver (Author/Creator) - The University of Western Australia
R. Lake (Author/Creator) - School of Medicine and Pharmacology
B.W.S. Robinson (Author/Creator) - The University of Western Australia
Publication Details: OncoImmunology, Vol.1(6), pp.840-846
Publisher: Landes Bioscience
Identifiers: 991005544393607891
Copyright: © 2012 Landes Bioscience
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.358 Dendritic Cell Therapy
Web Of Science research areas: Immunology; Oncology
ESI research areas: Biology & Biochemistry