Type-I Hemins and free porphyrins from a Western Australian Sponge Isabela sp

Samuele Sala; Stephen A Moggach; Gareth L Nealon; Jane Fromont; Oliver Gomez; Daniel Vuong; Ernest Lacey; Gavin R Flematti

doi:10.3390/md21010041

Back

Type-I Hemins and free porphyrins from a Western Australian Sponge Isabela sp

Journal article

Open access

Peer reviewed

Type-I Hemins and free porphyrins from a Western Australian Sponge Isabela sp

Samuele Sala, Stephen A Moggach, Gareth L Nealon, Jane Fromont, Oliver Gomez, Daniel Vuong, Ernest Lacey and Gavin R Flematti

Marine drugs, Vol.21(1), Art. 41

2023

DOI: https://doi.org/10.3390/md21010041

PMID: 36662214

Files and links (1)

pdf

Published1.05 MBDownload View

CC BY V4.0, Open Access

Abstract

Animals

Australia

Cell Line, Tumor

Ferric Compounds

Hemin - metabolism

Magnetic Resonance Spectroscopy

Mice

Multiple Myeloma

Porifera - metabolism

Porphyrins - pharmacology

Two novel free porphyrins, isabellins A and B, as well as the known compounds corallistin D and deuteroporphyrin IX were isolated from a marine sponge sp. LC-MS analysis of the crude extract revealed that the natural products were present both as free porphyrins and iron(III) coordinated hemins, designated isabellihemin A, isabellihemin B, corallistihemin D and deuterohemin IX, respectively. Structures were determined via high-resolution mass spectrometry, UV-Vis spectroscopy and extensive NOESY NMR spectroscopic experiments. The type-I alkyl substitution pattern of isabellin A and isabellihemin A was assigned unambiguously by single crystal X-ray diffraction. Biological evaluation of the metabolites revealed potent cytotoxicity for isabellin A against the NS-1 murine myeloma cell line.

Details

Title: Type-I Hemins and free porphyrins from a Western Australian Sponge Isabela sp
Authors/Creators: Samuele Sala - The University of Western Australia
Stephen A Moggach - School of Molecular Sciences, The University of Western Australia, Crawley, WA 6009, Australia
Gareth L Nealon - Centre for Microscopy, Characterisation and Analysis, The University of Western Australia, Crawley, WA 6009, Australia
Jane Fromont - Collection and Research, Western Australian Museum, Welshpool, WA 6106, Australia
Oliver Gomez - Collection and Research, Western Australian Museum, Welshpool, WA 6106, Australia
Daniel Vuong - Microbial Screening Technologies Pty. Ltd., Smithfield, NSW 2164, Australia
Ernest Lacey - Microbial Screening Technologies Pty. Ltd., Smithfield, NSW 2164, Australia
Gavin R Flematti - School of Molecular Sciences, The University of Western Australia, Crawley, WA 6009, Australia
Publication Details: Marine drugs, Vol.21(1), Art. 41
Identifiers: 991005564668907891
Murdoch Affiliation: Australian National Phenome Centre; Centre for Computational and Systems Medicine
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Metrics

123 File views/ downloads

57 Record Views

5 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.198 Mycotoxins; 3.198.749 Porifera
Web Of Science research areas: Chemistry, Medicinal; Pharmacology & Pharmacy
ESI research areas: Pharmacology & Toxicology