Vasomotor responses to hypoxia in type 2 diabetes

Cara J. Weisbrod; Peter R. Eastwood; Gerard O’Driscoll; Jennifer H. Walsh; Matthew Best; John R. Halliwill; Daniel J. Green

doi:10.2337/diabetes.53.8.2073

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Vasomotor responses to hypoxia in type 2 diabetes

Journal article

Peer reviewed

Vasomotor responses to hypoxia in type 2 diabetes

Cara J. Weisbrod, Peter R. Eastwood, Gerard O’Driscoll, Jennifer H. Walsh, Matthew Best, John R. Halliwill and Daniel J. Green

Diabetes (New York, N.Y.), Vol.53(8), pp.2073-2078

2004

DOI: https://doi.org/10.2337/diabetes.53.8.2073

PMID: 15277388

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Abstract

Type 2 diabetes is associated with vascular dysfunction, accelerated atherosclerotic morbidity, and mortality. Abnormal vasomotor responses to chemoreflex activation may contribute to the acceleration of atherosclerotic diabetes complications, but these responses have not previously been investigated. We measured forearm mean blood flow (MBF) and mean vascular conductance (MVC) responses to isocapnic hypoxia in seven healthy and eight type 2 diabetic subjects during local intra-arterial saline infusion and α-adrenergic blockade (phentolamine). The effects of hypoxia on saline and phentolamine responses significantly differed between groups; relative to normoxia, the %ΔMVC with hypoxia during saline was −3.3 ± 11.2% in control and 24.8 ± 13.3% in diabetic subjects, whereas phentolamine increased hypoxic %ΔMVC to similar levels (39.4 ± 9.7% in control subjects and 48.0 ± 11.8% in diabetic subjects, P < 0.05, two-way ANOVA). Absolute normoxic MBF responses during saline infusion were 91.9 ± 21.1 and 77.9 ± 15.3 in control and diabetic subjects, respectively, and phentolamine increased normoxic MBF to similar levels (165.2 ± 40.1 ml/min in control subjects and 175.9 ± 32.0 ml/min in diabetic subjects; both P < 0.05). These data indicate that diabetic and control subjects exhibit similar responses to hypoxia in the presence of α-adrenergic blockade despite evidence of exaggerated α-mediated vasoconstriction at rest.

Details

Title: Vasomotor responses to hypoxia in type 2 diabetes
Authors/Creators: Cara J. Weisbrod - The University of Western Australia
Peter R. Eastwood - Sir Charles Gairdner Hospital
Gerard O’Driscoll - School of Human Movement and Exercise Science, The University of Western Australia, Crawley, Australia, Cardiac Transplant Unit, Department of Cardiology, Royal Perth Hospital, Perth, Australia
Jennifer H. Walsh - The University of Western Australia
Matthew Best - Royal Perth Hospital
John R. Halliwill - University of Oregon
Daniel J. Green - The University of Western Australia
Publication Details: Diabetes (New York, N.Y.), Vol.53(8), pp.2073-2078
Identifiers: 991005592766907891
Copyright: © 2004 by the American Diabetes Association
Murdoch Affiliation: Vice Chancellery
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.218 Autonomic Regulation; 1.218.642 Heart Rate Variability
Web Of Science research areas: Endocrinology & Metabolism
ESI research areas: Clinical Medicine