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Published (Version of Record)CC BY-NC V4.0, Open Access
Journal article
Western Australian pregnancy cohort (Raine) Study: Generation 1
BMJ open, Vol.9(5), e026276
2019
PMCID: PMC6549642
PMID: 31138581
Abstract
Purpose: The purpose of the Raine Study is to improve human health and well-being by studying the life-course of a cohort of Western Australians, based on a life-course conceptual framework that considers interactions between genetics, phenotypes, behaviours, the environment and developmental and social outcomes.
Participants: Between May 1989 and November 1991, 2900 pregnant women were enrolled in the Raine Study in Perth, Western Australia. In total, 2730 women gave birth to 2868 children (Generation 2) between August 1989 and April 1992. The mothers and fathers of Generation 2 are referred to as Generation 1 of the Raine Study. In the most recent Generation 1 follow-up, 636 mothers and 462 fathers participated.
Findings to date: Until the 26-year follow-up of Generation 1 the focus of research within the Raine Study was on outcomes in Generation 2, with information on the parents mainly being used to examine its influence on their children’s outcomes. For example, recent findings showed that several characteristics of mothers, such as obesity, early mid-gestational weight gain and socioeconomic status were associated with non-alcoholic fatty liver disease, adiposity and cardiometabolic characteristics in offspring. Other findings showed that parents with back pain were more likely to have offspring who experienced back pain. Also, non-linear and dynamic relationships were found between maternal working hours and offspring overweight or obesity.
Future plans: The Raine Study will continue to provide access to its dense longitudinal genetic, phenotypic, behavioural, environmental, developmental and social data to undertake studies with the ultimate goal of improving human health and well-being. Analyses of data from the recent Generation 1 year 26 follow-up are underway.
Details
- Title
- Western Australian pregnancy cohort (Raine) Study: Generation 1
- Authors/Creators
- Manon L. Dontje - The University of Western AustraliaPeter Eastwood - The University of Western AustraliaLeon Straker - Curtin University
- Publication Details
- BMJ open, Vol.9(5), e026276
- Publisher
- Bmj Publishing Group
- Number of pages
- 11
- Grant note
- 6006; 14123 / Healthway Princess Margaret Hospital Foundation Gastroenterology Society of Australia Rotary Health Research Western Australia Department of Health Targeted Research Fund Telstra Foundation Asthma Foundation of Western Australia Edith Cowan University Curtin University Glaxo Wellcome National Heart Foundation; National Heart Foundation of Australia University of Western Australia Cardiovascular Lipid Pfizer Grant Smarttots Ada Bartholomew Medical Research Trust Stanley Trust (UK) Raine Medical Research Foundation Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR) Asthma Foundation Women and Infants Research Foundation University of Notre Dame Australia Fremantle Hospital Medical Research Foundation Channel 7 Telethon Trust Murdoch University Danish Council for Strategic Studies 880441; 930745; 963209; 211912; 003209; 32300; 403981; 353514; 458623; 403968; 572613; 1084947; 1080492 / National Health and Medical Research Council of Australia; National Health and Medical Research Council (NHMRC) of Australia Dairy Health and Nutrition Consortium King Edward Memorial Hospital Research Foundation Australian Arthritis Foundation Telethon Kids Institute Western Australia Department of Health Future Health Fund
- Identifiers
- 991005592643507891
- Copyright
- © Author(s) (or their employer(s)) 2019
- Murdoch Affiliation
- Vice Chancellery
- Language
- English
- Resource Type
- Journal article
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- Web Of Science research areas
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