Jessica Cale

I am a Research Fellow with the Personalised Medicine Centre (formerly the Centre for Molecular Medicine and Innovative Therapeutics). I specialise in developing and applying short synthetic nucleic acid sequences called antisense oligonucleotides as therapies for rare diseases, diseases of aging, and global health disorders. After completing my PhD in 2021, I have been involved in several commercial-in-confidence, industry-funded research projects with Senisca Ltd. (UK), Lyramid Ltd. (Australia) and Sarepta Therapeutics (US). In these roles, I have provided expertise in designing, optimising, and validating antisense therapies for healthy aging, cancer and neuromuscular diseases. I am particularly driven by the unmet needs of children with rare diseases. My current grant-funded research focuses on developing antisense therapies for children with rare diseases and creating patient-derived disease models for preclinical testing of these treatments.