Dr Nicola Gray

My research is centred on understanding the complex interactions between our genetics, environment and lifestyle in health and disease through the application of metabolic phenotyping to reveal chemical changes in several disease areas. This approach focuses on the use of analytical techniques, specifically liquid chromatography-mass spectrometry (LC-MS), to elucidate molecular changes that correlate with health outcomes. My goals are to develop and apply novel MS-based approaches to investigate metabolism and characterise metabolic signatures of disease. This program aims to advance and harmonise workflows for the quantification of metabolites in biofluids, resulting in analytical approaches that permit robust and informative analysis of large scale population studies. The overarching goal is to enhance our understanding of disease development and risk leading to prevention, better detection or stratification of treatment for improved health outcomes.