Output list
Conference proceeding
Published 2000
Major Histocompatibility Complex: Evolution, Structure, and Function, 146 - 157
6th International Workshop on MHC Evolution, 25/05/1999–29/05/1999, Hayama, Japan
The major histocompatibility complex (MHC) region contains several hundred genes in addition to the well-known HLA Class I and II loci. Some of these will explain MHC-disease associations. We have used paralogous and syntenic mapping to short list candidates and conclude that non-HLA genes present on human 6,1 and 19 and murine 17, 4 and 7 regulate immune responses and autoimmune disease. These genes are likely to be components of the early pre-HLA MHC and include tenascin and possibly notch inter alia.